XFile has been tested on the pre-release version of the ActiveX update and responds to the activation changes as described in the white paper.
You can still script against XFile for client-side automation. You will not need to make any changes to your code.
For User Interaction (use of XFile's GUI):
The user will need to click on XFile's GUI in order to activate it. After the user has activated the control, it will work as it always has.
MSDN white paper: http://msdn.microsoft.com/library/?url=/workshop/author/dhtml/overview/activating_activex.asp