It is possible to have FileUp save your uploaded files to a network share, as long as your share and NTFS permissions are set up correctly for the upload directory*; however, using mapped drives is not recommended. Why? This is because mapped drives are part of user-specific settings. The account your application is running under may not have the particular mapped drive set up. Of course, you may choose to set this mapped drive up for your application identity, but we recommend using UNC paths instead. For example:

 oFileUp.SaveAs "\\ServerName\UploadDirectory\Filename.txt"

UNC paths are not dependent on the user account and will always be available if the network connection is intact.

*please see Error Saving File to a Network Share